Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

587
Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
587
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

2.1K
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
2.1K
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

3.8K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
3.8K
Overview of the Vascular System01:20

Overview of the Vascular System

3.7K
The vascular system comprises an extensive network of arteries, capillaries, and veins. The vascular system can be broadly divided into the blood and lymphatic systems. Typically, blood vessels can be categorized into three histological regions: tunica intima, tunica media, and tunica adventitia. The tunica intima consists of a single layer of endothelial cells attached to the basal lamina. Underlying the basal lamina is a connective tissue layer and an elastic lamina that gives stability and...
3.7K
Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

3.7K
Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
3.7K
Disorders of Hemostasis01:24

Disorders of Hemostasis

2.5K
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
2.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Safety, complications and clinical outcome after ultrasound-guided paravertebral catheter insertion for rib fracture analgesia: a single-centre retrospective observational study.

Anaesthesia·2019
Same author

Evolutionary, biosocial, and cross-cultural perspectives on the variability in human biological aging.

American journal of human biology : the official journal of the Human Biology Council·2017
Same author

Attitudes and perceptions concerning elderly Samoans in rural Western Samoa, American Samoa, and urban Honolulu.

Journal of cross-cultural gerontology·2014
Same author

Aberrant expression and biological significance of Sox2, an embryonic stem cell transcriptional factor, in ALK-positive anaplastic large cell lymphoma.

Blood cancer journal·2012
Same author

Vascular smooth muscle cells : isolation, culture, and characterization.

Methods in molecular medicine·2011
Same author

Endothelial progenitor cells - hype or hope?

Journal of thrombosis and haemostasis : JTH·2009
Same journal

Preface

Bailliere's best practice & research. Clinical haematology·2000
Same journal

Index

Bailliere's best practice & research. Clinical haematology·2000
Same journal

Biotechnology: alternatives to human plasma-derived therapeutic proteins.

Bailliere's best practice & research. Clinical haematology·2000
Same journal

Red blood cell substitutes.

Bailliere's best practice & research. Clinical haematology·2000
Same journal

The risks of transfusion-transmitted infection: direct estimation and mathematical modelling.

Bailliere's best practice & research. Clinical haematology·2000
Same journal

Will genome detection replace serology in blood screening for microbial agents?

Bailliere's best practice & research. Clinical haematology·2000
See all related articles

Related Experiment Video

Updated: Mar 2, 2026

In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time
09:19

In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time

Published on: May 24, 2020

9.8K

Endothelial cell function and thrombosis.

J D Pearson1

  • 1Centre for Cardiovascular Biology & Medicine, King's College London, UK.

Bailliere'S Best Practice & Research. Clinical Haematology
|June 17, 2000
PubMed
Summary
This summary is machine-generated.

The endothelium regulates blood clotting and thrombosis by producing key molecules. In disease, these endothelial cells shift towards a prothrombotic state, impacting haemostasis.

More Related Videos

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
12:50

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response

Published on: September 15, 2017

7.0K
A Novel In vitro Model for Studying the Interactions Between Human Whole Blood and Endothelium
06:27

A Novel In vitro Model for Studying the Interactions Between Human Whole Blood and Endothelium

Published on: November 21, 2014

10.0K

Related Experiment Videos

Last Updated: Mar 2, 2026

In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time
09:19

In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time

Published on: May 24, 2020

9.8K
Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
12:50

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response

Published on: September 15, 2017

7.0K
A Novel In vitro Model for Studying the Interactions Between Human Whole Blood and Endothelium
06:27

A Novel In vitro Model for Studying the Interactions Between Human Whole Blood and Endothelium

Published on: November 21, 2014

10.0K

Area of Science:

  • Vascular Biology
  • Haemostasis and Thrombosis
  • Endothelial Cell Biology

Background:

  • The endothelium plays a critical role in regulating haemostasis and thrombosis.
  • Healthy endothelial cells possess anticoagulant and antithrombotic properties.
  • These properties are mediated by secreted molecules like prostacyclin and nitric oxide.

Purpose of the Study:

  • To elucidate the multifaceted roles of endothelial cells in haemostasis and thrombosis.
  • To understand the mechanisms by which endothelial cells maintain an anticoagulant state.
  • To investigate how endothelial cell function is altered in disease states.

Main Methods:

  • Review of established literature on endothelial cell function in haemostasis.
  • Analysis of the molecular mechanisms underlying endothelial cell-mediated regulation of coagulation and fibrinolysis.
  • Examination of endothelial cell responses to vessel injury and inflammatory stimuli.

Main Results:

  • Endothelial cells secrete key antiplatelet agents (prostacyclin, nitric oxide) and coagulation regulators (thrombomodulin, antithrombin binding sites).
  • Endothelial cells produce von Willebrand Factor, crucial for platelet adhesion post-injury.
  • Endothelial cells release regulators of fibrinolysis (tissue-type plasminogen activator) and coagulation inhibition (Tissue Factor pathway inhibitor).

Conclusions:

  • Endothelial cells are central regulators of haemostasis and thrombosis, maintaining a non-thrombotic surface in health.
  • Disruption of endothelial cell function in disease promotes a prothrombotic phenotype.
  • Understanding these endothelial mechanisms is vital for developing therapies for thrombotic disorders.