Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sentinel node localization by lymphoscintigraphy: a reliable technique with widespread applications.

G Paganelli1, C De Cicco, M Chinol

  • 1Division of Nuclear Medicine, European Institute of Oncology, Milan, Italy.

Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progres Dans Les Recherches Sur Le Cancer
|June 17, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Peptide receptor radionuclide therapy in patients with metastatic progressive pheochromocytoma and paraganglioma: long-term toxicity, efficacy and prognostic biomarker data of phase II clinical trials.

ESMO open·2021
Same author

Clinical value of negative <sup>68</sup>Ga-PSMA PET/CT in the management of biochemical recurrent prostate cancer patients.

European journal of nuclear medicine and molecular imaging·2020
Same author

Combination radium-223 therapies in patients with bone metastases from castration-resistant prostate cancer: A review.

Critical reviews in oncology/hematology·2020
Same author

Circulating androgen receptor combined with 18F-fluorocholine PET/CT metabolic activity and outcome to androgen receptor signalling-directed therapies in castration-resistant prostate cancer.

Scientific reports·2017
Same author

Measurement of circulating transcripts and gene cluster analysis predicts and defines therapeutic efficacy of peptide receptor radionuclide therapy (PRRT) in neuroendocrine tumors.

European journal of nuclear medicine and molecular imaging·2015
Same author

Fluorodeoxyglucose positron emission tomography in pulmonary carcinoid tumors.

The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of...·2015
Same journal

Future Challenges of Molecular Imaging in Oncology.

Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer·2026
Same journal

Clinical Applications of Theranostics.

Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer·2026
Same journal

Internal Radiation Therapy.

Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer·2026
Same journal

The Role of Molecular Imaging in Ion Beam Therapy.

Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer·2026
Same journal

Molecular Imaging in Photon Radiotherapy.

Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer·2026
Same journal

Advancements in Intraoperative Imaging for Enhanced Surgical Precision.

Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer·2026
See all related articles

Sentinel lymph node (SN) biopsy, guided by lymphoscintigraphy (LS) and a gamma-detecting probe (GDP), accurately stages cancer. This nuclear medicine technique improves surgical guidance for early-stage cancers like breast carcinoma and melanoma.

Area of Science:

  • Nuclear Medicine
  • Oncology
  • Surgical Pathology

Background:

  • Accurate preoperative staging of lymph node status is crucial for guiding cancer surgery.
  • Sentinel lymph node (SN) biopsy, initially for melanoma, is now applied to other malignancies.
  • Early SN biopsy methods using vital blue dye had limitations, missing SN in up to 40% of cases.

Purpose of the Study:

  • To evaluate the efficacy of lymphoscintigraphy (LS) combined with a gamma-ray detecting probe (GDP) for SN biopsy.
  • To assess the accuracy of LS-guided SN biopsy in breast carcinoma and melanoma.
  • To explore the potential of LS-guided SN biopsy for other cancer types.

Main Methods:

  • Injection of a radioactive tracer near the tumor.
  • Identification of the SN using lymphoscintigraphy (LS) for imaging.

Related Experiment Videos

  • Localization of the SN's skin projection with a gamma-ray detecting probe (GDP) for biopsy.

    • Main Results:

    • In breast cancer patients, LS and GDP-guided SN biopsy achieved an overall predictive value of 96.8%.
    • For small breast carcinomas (<1.2 cm), concordance between SN and axillary status was 98.6%.
    • LS combined with GDP detected SN in 98% of melanoma cases, outperforming blue dye mapping (80% detection).

    Conclusions:

    • LS is a simple, cost-effective, and well-tolerated nuclear medicine technique.
    • SN biopsy guided by LS and GDP is increasingly adopted for various neoplasms.
    • This technique significantly aids in developing less aggressive treatments for early-stage cancers.