Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sentinel node detection in malignant melanoma.

A D Chan1, D L Morton

  • 1John Wayne Cancer Institute, Santa Monica, CA 90404-2302, USA.

Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progres Dans Les Recherches Sur Le Cancer
|June 17, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Detection of occult metastatic breast cancer cells in blood by a multimolecular marker assay: correlation with clinical stage of disease.

Cancer research·2001
Same author

Myo-electric signals to augment speech recognition.

Medical & biological engineering & computing·2001
Same author

The Augsburg Consensus. Techniques of lymphatic mapping, sentinel lymphadenectomy, and completion lymphadenectomy in cutaneous malignancies.

Cancer·2000
Same author

Judging the therapeutic value of lymph node dissections for melanoma.

Journal of the American College of Surgeons·2000
Same author

TA90-IC, a new marker for advanced colon cancer.

Annals of surgical oncology·2000
Same author

Cryosurgical ablation and radiofrequency ablation for unresectable hepatic malignant neoplasms: a proposed algorithm.

Archives of surgery (Chicago, Ill. : 1960)·2000

Sentinel lymph node biopsy (SLNB) aids in staging melanoma and other cancers by identifying metastasis. While accurate, its therapeutic benefits require further clinical trial validation.

Area of Science:

  • Oncology
  • Surgical Oncology
  • Nuclear Medicine

Background:

  • Lymphatic mapping and sentinel lymphadenectomy (LM/SL) followed by selective complete lymphadenectomy (SCLND) originated for melanoma staging.
  • It addressed the controversy surrounding immediate versus delayed lymph node dissection.
  • Advances in nuclear medicine, surgery, and pathology have popularized SLNB for melanoma and other lymphatic-progressing solid tumors.

Purpose of the Study:

  • To review the current status and ongoing debates surrounding LM/SL/SCLND.
  • To highlight the diagnostic accuracy and discuss the therapeutic implications of the procedure.
  • To examine key issues including nomenclature, occult metastasis, quality assurance, and use in non-melanoma centers.

Main Methods:

  • Review of existing literature and multicenter trial data on LM/SL/SCLND.

Related Experiment Videos

  • Discussion of advancements in nuclear medicine, surgical techniques, and pathology for sentinel node identification.
  • Analysis of current controversies and future research directions.

    • Main Results:

    • LM/SL/SCLND is widely adopted for melanoma due to demonstrated diagnostic accuracy.
    • The procedure's application has expanded to other solid tumors with lymphatic spread.
    • Therapeutic benefits require further confirmation through robust clinical trials.

    Conclusions:

    • Sentinel lymph node biopsy is a valuable diagnostic tool but requires more evidence for therapeutic claims.
    • Ongoing research addresses nomenclature, occult disease significance, quality control, and broader clinical application.
    • Further well-designed trials are essential to establish definitive therapeutic benefits.