Perfluoroperhydrophenanthrene versus perfluoro-n-octane in vitreoretinal surgery

Area of Science:

• Ophthalmology
• Retinal Surgery
• Surgical Materials

Background:

• Perfluorocarbon liquids are utilized in retinal detachment surgery.
• Comparing different perfluorocarbon liquids is crucial for optimizing surgical outcomes.

Purpose of the Study:

• To compare perfluoro-n-octane (PFO) and perfluoroperhydrophenanthrene (Vitreon) in terms of surgical removal ease, efficacy, and safety.
• To evaluate the impact of these liquids on visual acuity, intraocular pressure, and retinal attachment.

Main Methods:

• Retrospective, nonrandomized comparative trial involving 264 patients.
• Medical records were reviewed for patients who received either Vitreon (n=142) or PFO (n=122).
• Efficacy and safety were assessed in a subset of patients with severe retinal detachment (PVR grade C or more) with at least 6 months follow-up.

Main Results:

• Perfluoro-n-octane (PFO) showed a lower rate of retained perfluorocarbon at 6 months (4%) compared to Vitreon (8.4%).
• No statistically significant differences were observed in retinal attachment rates (71.7% Vitreon vs. 78.3% PFO) or visual acuity outcomes between the two groups.
• A trend towards clearer corneas was noted in the Vitreon group at 12 months.

Conclusions:

• Perfluoro-n-octane (PFO) is easier to visualize and completely remove during surgery.
• Both PFO and Vitreon exhibit comparable efficacy in achieving retinal attachment and improving visual outcomes.
• The choice between PFO and Vitreon may depend on surgical preference regarding ease of removal versus potential long-term corneal clarity.