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Updated: Aug 9, 2026
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Database-guided Flow-cytometry for Evaluation of Bone Marrow Myeloid Cell Maturation
Published on: November 3, 2018
[Bone mastocytosis. Diagnostic approach]
M B Sánchez Montero1, L M Vaquero Roncero, M Arias Paciencia
1Servicio de Medicina Interna, Familiar y Comunitaria, Hospital Virgen de la Concha, Zamora.
Anales De Medicina Interna (Madrid, Spain : 1984)
|June 22, 2000
Summary
Systemic mastocytosis involves mast cell accumulation. Bone mastocytosis, affecting 70-90% of patients, requires clearer diagnostic criteria based on clinical, radiological, and pathological findings.
Area of Science:
- Hematology
- Oncology
- Pathology
Context:
- Mastocytosis comprises disorders of mast cell accumulation.
- Systemic mastocytosis (SM) is diagnosed when organs/tissues are affected beyond the skin.
- Bone mastocytosis is a common manifestation of SM, affecting 70-90% of patients, yet lacks standardized diagnostic criteria.
Purpose:
- To review characteristic findings in bone mastocytosis.
- To establish diagnostic criteria for bone mastocytosis.
- To analyze clinical, analytical, radiological, and pathological variables for diagnosing SM and bone mastocytosis.
Summary:
- This study reviewed 213 cases of bone mastocytosis from literature published between 1977 and 1997.
- Key findings related to clinical, analytical, radiological, and pathological variables were analyzed.
- The goal was to identify features crucial for diagnosing systemic mastocytosis and bone mastocytosis.
Impact:
- This review aims to improve the diagnosis of bone mastocytosis.
- Establishing clear diagnostic criteria will aid in patient management.
- Enhanced understanding of bone mastocytosis contributes to the broader field of mast cell disorders.
