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Related Experiment Video

Updated: Jun 24, 2026

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells

Published on: November 23, 2014

[Neoplastic angiogenesis].

P Khosravi Shahi¹, A Del Castillo Rueda, G Pérez Manga

¹Servicio de Oncología Médica, Hospital General Universitario Gregorio Marañón, Madrid, España. drkhosravi@hotmail.com

Anales De Medicina Interna (Madrid, Spain : 1984)

|March 20, 2009

Summary

This summary is machine-generated.

Neoplastic angiogenesis, crucial for tumor growth and metastasis, is targeted by therapies like bevacizumab and multi-kinase inhibitors. These treatments inhibit vascular endothelial growth factor (VEGF) and other key receptors, showing promise in cancer treatment.

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Area of Science:

Oncology
Molecular Biology
Cancer Research

Context:

Neoplastic angiogenesis is vital for tumor progression and metastasis.
Vascular Endothelial Growth Factor (VEGF) plays a critical role in tumor angiogenesis.
Targeting angiogenesis is a key strategy in cancer therapy.

Purpose:

To review the role of VEGF in neoplastic angiogenesis.
To discuss anti-angiogenic therapies targeting VEGF and other receptors.
To highlight the clinical application of these therapies in various cancers.

Summary:

Angiogenesis, the formation of new blood vessels, is essential for tumor growth and metastasis.
VEGF is a key mediator of neoplastic angiogenesis, making it a significant therapeutic target.
Bevacizumab, an anti-VEGF antibody, and multi-kinase inhibitors (sorafenib, sunitinib) targeting VEGFR and PDGFR are used to treat advanced renal-cell carcinoma and are being investigated in other tumors.

Impact:

Anti-angiogenic therapies offer a novel approach to cancer treatment by inhibiting tumor vascularization.
Targeting VEGF and related pathways can potentially improve chemotherapy delivery to tumors.
These therapies represent an important advancement in the management of advanced cancers, with ongoing research exploring broader applications.