Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Disorders of the Male Reproductive System

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...

Spermatogenesis

Spermatogenesis

Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male reproductive...

Spermatogenesis

Spermatogenesis

Spermatogenesis is a complex process that involves the development of sperm cells from undifferentiated stem cells in the seminiferous tubules of the testes. The process is essential for the production of mature and functional sperm cells that are capable of fertilizing an egg.
The process of spermatogenesis can be divided into mitosis, meiosis, and spermiogenesis. During mitosis, the spermatogonia or stem cells divide to produce two identical daughter cells, type A and B spermatogonia. Type-A...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Cabozantinib plus nivolumab and ipilimumab in previously untreated, advanced renal cell carcinoma: final results and biomarker analyses from the phase III COSMIC-313 study.

Annals of oncology : official journal of the European Society for Medical Oncology·2026

Same author

Avelumab plus sacituzumab govitecan versus avelumab monotherapy as first-line maintenance treatment in patients with advanced urothelial carcinoma: JAVELIN Bladder Medley interim analysis.

Annals of oncology : official journal of the European Society for Medical Oncology·2025

Same author

Pembrolizumab plus enzalutamide versus placebo plus enzalutamide for chemotherapy-naive metastatic castration-resistant prostate cancer: the randomized, double-blind, phase III KEYNOTE-641 study.

Annals of oncology : official journal of the European Society for Medical Oncology·2025

Same author

Effect of adjuvant chemotherapy in locally advanced urothelial carcinoma of the bladder treated with cystectomy.

Actas urologicas espanolas·2019

Same author

[Highly aggresive pulmonary epithelioid hemangioendothelioma: a case report].

Anales del sistema sanitario de Navarra·2017

Same author

Validation of the International Metastatic Renal-Cell Carcinoma Database Consortium (IMDC) prognostic model for first-line pazopanib in metastatic renal carcinoma: the Spanish Oncologic Genitourinary Group (SOGUG) SPAZO study.

Annals of oncology : official journal of the European Society for Medical Oncology·2015

Same journal

[Neoplastic angiogenesis].

Anales de medicina interna (Madrid, Spain : 1984)·2009

Same journal

[Immune response in optic neuromyelitis].

Anales de medicina interna (Madrid, Spain : 1984)·2009

Same journal

[Autoimmune pancreatitis. Related to a case].

Anales de medicina interna (Madrid, Spain : 1984)·2009

Same journal

[Severe ocular symptoms as an initial manifestation of superior vena cava syndrome].

Anales de medicina interna (Madrid, Spain : 1984)·2009

Same journal

[Diagnosis of the spontaneous subarachnoid hemorrhage with short bleeding or long evolution: report of one case].

Anales de medicina interna (Madrid, Spain : 1984)·2009

Same journal

[Gastroesophageal reflux as a cause of vocal dysfunction].

Anales de medicina interna (Madrid, Spain : 1984)·2009

See all related articles

Search research articles

Related Experiment Video

Updated: Jul 2, 2026

Germ Cell Transplantation and Testis Tissue Xenografting in Mice

Germ Cell Transplantation and Testis Tissue Xenografting in Mice

Published on: February 6, 2012

[Mediastinal germ-cell tumours].

V M Díaz Muñoz de la Espada¹, P Khosravi Shahi, B Hernández Marín

¹Servicio de Oncología Médica, Hospital General Universitario Gregorio Marañón, Madrid, Spain. vdm1978@hotmail.com

Anales De Medicina Interna (Madrid, Spain : 1984)

|September 5, 2008

Summary

This summary is machine-generated.

Mediastinal germ-cell tumors (MGCT) are rare cancers occurring outside the testes, often in the body midline. Early diagnosis is crucial as these curable tumors respond well to chemotherapy.

More Related Videos

Transgenic Rodent Assay for Quantifying Male Germ Cell Mutant Frequency

Transgenic Rodent Assay for Quantifying Male Germ Cell Mutant Frequency

Published on: August 6, 2014

Related Experiment Videos

Last Updated: Jul 2, 2026

Germ Cell Transplantation and Testis Tissue Xenografting in Mice

Germ Cell Transplantation and Testis Tissue Xenografting in Mice

Published on: February 6, 2012

Transgenic Rodent Assay for Quantifying Male Germ Cell Mutant Frequency

Transgenic Rodent Assay for Quantifying Male Germ Cell Mutant Frequency

Published on: August 6, 2014

Area of Science:

Oncology
Pathology
Medical Diagnosis

Context:

Germ-cell tumors (GCTs) typically originate in the testes.
A small percentage (2-5%) of male GCTs present as primary extragonadal tumors.
These extragonadal GCTs commonly occur along the body's midline, particularly in the mediastinum and retroperitoneum.

Purpose:

To review the histopathologic and clinical characteristics of mediastinal germ-cell tumors (MGCT).
To differentiate MGCTs from their testicular counterparts.
To emphasize the importance of including MGCT in the differential diagnosis of mediastinal masses.

Summary:

Primary mediastinal germ-cell tumors (MGCT) are infrequent extragonadal GCTs.
They present in the mediastinum or retroperitoneum without evidence of a testicular primary tumor.
Accurate diagnosis is vital for effective treatment, as MGCTs are curable with chemotherapy.

Impact:

Highlights the significance of considering MGCT in unexplained mediastinal tumors.
Underscores the curability of these rare tumors with appropriate chemotherapy.
Aids clinicians in distinguishing extragonadal GCTs from testicular GCTs for better patient management.