Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

5-Hydroxytryptophan toxicosis in dogs: 21 cases (1989-1999).

S M Gwaltney-Brant1, J C Albretsen, S A Khan

  • 1ASPCA National Animal Poison Control Center, Urbana, IL 61802, USA.

Journal of the American Veterinary Medical Association
|June 23, 2000
PubMed
Summary

Accidental ingestion of 5-hydroxytryptophan (5-HTP) in dogs can cause severe neurologic and gastrointestinal signs, mimicking human serotonin syndrome. Prompt veterinary treatment is crucial for recovery from 5-HTP toxicosis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Midrapidity antiproton-to-proton ratio in pp collisons at sqrt[s]=0.9 and 7 TeV measured by the ALICE experiment.

Physical review letters·2010
Same author

An updated checklist of species of Aedes and Verrallina of northeastern India.

Journal of the American Mosquito Control Association·2010
Same author

Arthroscopic debridement of docking site in Ilizarov bone transport.

Annals of the Royal College of Surgeons of England·2010
Same author

Modified perfusion fluid for renal transplantation in developing countries: our initial experience.

Transplantation proceedings·2010
Same author

Variation of resistance in barley against biotypes 1 and 2 of the Russian wheat aphid (Hemiptera: Aphididae).

Journal of economic entomology·2010
Same author

Gelatin nanoparticle preparation by nanoprecipitation.

Journal of biomaterials science. Polymer edition·2010

Area of Science:

  • Veterinary Toxicology
  • Canine Pharmacology
  • Animal Health

Background:

  • 5-hydroxytryptophan (5-HTP) is a precursor to serotonin, a neurotransmitter.
  • Accidental ingestion of 5-HTP supplements can occur in dogs.
  • Understanding the toxic effects of 5-HTP in dogs is important for veterinary care.

Purpose of the Study:

  • To characterize the epidemiologic features of 5-hydroxytryptophan (5-HTP) toxicosis in dogs.
  • To identify clinical signs associated with 5-HTP toxicosis.
  • To evaluate the treatment outcomes for dogs with 5-HTP toxicosis.

Main Methods:

  • A retrospective study design was employed.
  • Data were collected from 21 dogs with confirmed accidental 5-HTP ingestion via the National Animal Poison Control Center database.

Related Experiment Videos

  • Records were reviewed for signalment, ingested dose, clinical signs, treatments, and outcomes.

    • Main Results:

    • Ninety percent of dogs (19/21) developed clinical signs of toxicosis.
    • Common signs included neurologic (seizures, tremors, ataxia) and gastrointestinal (vomiting, diarrhea) symptoms, along with hyperthermia.
    • The minimum toxic dose was 23.6 mg/kg, and the minimum lethal dose was 128 mg/kg; 16 of 17 treated dogs recovered.

    Conclusions:

    • 5-hydroxytryptophan (5-HTP) ingestion in dogs can lead to a life-threatening condition similar to human serotonin syndrome.
    • Clinical signs can manifest rapidly (within 10 minutes to 4 hours) and persist for up to 36 hours.
    • Aggressive and prompt veterinary intervention, including decontamination and supportive care, is essential for successful outcomes.