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Severe neonatal group A streptococcal disease
M A Verboon-Maciolek1, T G Krediet, I van Ertbruggen
1Department of Neonatology, Wilhelmina Children's Hospital, University Medical Centre, Utrecht, The Netherlands. m.verboon@wkz.azu.nl
European Journal of Pediatrics
|June 27, 2000
Summary
Group A streptococcal infections are rising in adults and children, but remain rare in newborns. This study highlights the severe presentation and potential vertical transmission of group A strep in neonates.
Area of Science:
- Neonatal Medicine
- Infectious Diseases
- Microbiology
Background:
- Invasive disease caused by group A streptococci (GAS) has increased in adults and children since the mid-1980s.
- Neonatal GAS disease, while rare, can be severe.
- A rise in invasive group A streptococcal disease necessitates awareness of neonatal risks.
Purpose of the Study:
- To describe the clinical presentation, treatment, and outcomes of severe group A streptococcal disease in neonates.
- To document cases of vertical transmission in early-onset neonatal GAS disease.
- To emphasize the importance of recognizing neonatal group A streptococcal disease.
Main Methods:
- Retrospective review of seven neonates with severe group A streptococcal disease admitted to a neonatal intensive care unit between 1979 and 1998.
- Analysis of clinical data, including presentation, treatment, and outcomes.
- Documentation of vertical transmission in cases of early-onset disease.
Main Results:
- Seven neonates with severe group A streptococcal disease were identified over a 20-year period.
- Clinical presentations, treatments, and outcomes were detailed for these cases.
- Vertical transmission was confirmed in three cases of early-onset neonatal GAS disease.
Conclusions:
- Increased incidence of group A streptococcal disease in the general population warrants heightened awareness of neonatal cases.
- Neonatal group A streptococcal disease can be severe and requires prompt recognition and management.
- Understanding transmission routes, including vertical transmission, is crucial for prevention and treatment strategies.