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An Alkali-burn Injury Model of Corneal Neovascularization in the Mouse

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[Corneal infection, cause and effect on vision].

Y Domniz¹, R Avisar, H Savir

¹Ophthalmology Depts., Assaf Harofeh Medical Center, Zerifin.

|June 27, 2000

Summary

A 5-year survey revealed Staphylococcus albus as the most common cause of corneal infections, contrary to global reports. Pseudomonas aeruginosa significantly worsened vision, especially in contact lens wearers.

Area of Science:

Ophthalmology
Infectious Diseases
Microbiology

Context:

Corneal infections pose a significant threat to vision.
Understanding causative agents and their virulence is crucial for effective treatment.
Previous literature suggests low virulence for Staphylococcus albus.

Purpose:

To retrospectively analyze the epidemiology and outcomes of corneal infections treated at Hasharon Hospital over a 5-year period.
To identify the most frequent types and causes of corneal infections.
To assess visual acuity outcomes and identify risk factors for poor prognosis.

Summary:

The study identified corneal abscess as the most frequent type of corneal infection.
Staphylococcus albus was the most common causative agent, despite its reported low virulence globally, suggesting potentially higher virulence in the Israeli population.

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Pseudomonas aeruginosa was the leading cause of vision decline and the primary pathogen in contact lens-related infections.

Visual acuity improved in 69.2% of patients, with corneal ulcers showing the greatest improvement and corneal abscesses associated with the worst outcomes.

Impact:

This research highlights a potential shift in the virulence of Staphylococcus albus in corneal infections within a specific geographic region.
Findings emphasize the importance of considering local epidemiological data for Staphylococcus albus in diagnosing and managing corneal infections.
The study underscores the severe visual impact of Pseudomonas aeruginosa, particularly in contact lens wearers, necessitating targeted preventive strategies.