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Related Experiment Videos

MR venography of multiple sclerosis.

I L Tan1, R A van Schijndel, P J Pouwels

  • 1Department of Radiology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands.

AJNR. American Journal of Neuroradiology
|June 28, 2000
PubMed
Summary

Magnetic resonance venography reveals that multiple sclerosis (MS) brain lesions exhibit a perivenous distribution. This imaging technique visualizes how venous anatomy influences the characteristic shape and orientation of MS lesions in vivo.

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Area of Science:

  • Neuroimaging
  • Neurology
  • Radiology

Background:

  • Multiple sclerosis (MS) brain lesions typically occur in periventricular and deep white matter regions.
  • Histopathologic studies indicate a perivenous distribution pattern for MS lesions.

Purpose of the Study:

  • To visualize the in vivo distribution patterns of MS brain lesions using high-resolution MR venography.
  • To correlate observed lesion distribution with underlying venous anatomy.

Main Methods:

  • Seventeen MS patients underwent 1.5 T MRI.
  • MR venography was performed using a 3D gradient-echo technique.
  • MS lesions on T2-weighted images were analyzed for shape, orientation, and location relative to venous anatomy.

Main Results:

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  • Contrast-enhanced MR venography improved visualization of small veins.
  • A central vein was identified in 100% of periventricular and 98% of deep white matter MS lesions.
  • The ovoid shape and long axis orientation of MS lesions correlated with adjacent venous structures.

Conclusions:

  • MR venography effectively visualizes the perivenous distribution of MS brain lesions in vivo.
  • Venous anatomy plays a crucial role in defining the characteristic morphology and orientation of MS lesions.