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Sorting and transport in C. elegans: aA model system with a sequenced genome.
1Department of Anatomy and Neurobiology, Box 8108, 660 South Euclid Avenue, Washington University School of Medicine, St. Louis, MO 63110, USA. sandhya@thalamus.wustl.edu.
Current Opinion in Cell Biology
|June 30, 2000
Summary
Caenorhabditis elegans is emerging as a key model for studying protein transport. New in vivo assays reveal gene functions in endocytosis and neuronal transport.
Area of Science:
- Cell Biology
- Molecular Biology
- Neuroscience
Background:
- Yeast and cultured cells have traditionally been used to study protein sorting and transport.
- Recent advances in experimental techniques and genomics have spurred research in Caenorhabditis elegans.
Purpose of the Study:
- To investigate the roles of genes in protein sorting and transport using Caenorhabditis elegans.
- To apply new in vivo assays to monitor cellular processes.
Main Methods:
- Utilized Caenorhabditis elegans as a model organism.
- Employed novel in vivo assays to track endocytosis and neuronal transport.
Main Results:
- Identified and delineated the functions of several genes involved in these processes.
- Demonstrated the utility of new assays for studying protein transport in vivo.
Conclusions:
- Caenorhabditis elegans is a powerful model for studying protein transport.
- New in vivo assays are effective tools for gene function discovery in endocytosis and neuronal transport.