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Updated: Aug 3, 2026

Quantitative Polymerase Chain Reaction (qPCR)-Based Rapid Diagnosis of Helicobacter pylori Infection and Antibiotic Resistance
06:40

Quantitative Polymerase Chain Reaction (qPCR)-Based Rapid Diagnosis of Helicobacter pylori Infection and Antibiotic Resistance

Published on: July 28, 2023

[The assessment of Helicobacter pylori eradication with the urea breathing test (13C UBT)]

M Zajaczkowska1, T Durakiewicz, A Papierkowski

  • 1Kliniki Pediatrii i Nefrologii AM w Lublinie.

Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego
|July 18, 2000
PubMed

Insights

Helicobacter pylori (HP) infection treatment is effective in children with nephrotic syndrome. The non-invasive 13C urea breath test (13C UBT) accurately assesses treatment success in these patients.

Area of Science:

  • Pediatric Nephrology
  • Gastroenterology
  • Infectious Diseases

Background:

  • Nephrotic syndrome is a kidney disorder affecting children.
  • Helicobacter pylori (HP) infection is common and can cause gastrointestinal issues.
  • The link between HP infection and nephrotic syndrome requires further investigation.

Purpose of the Study:

  • To evaluate the effectiveness of HP infection treatment in children with nephrotic syndrome.
  • To assess the utility of the 13C urea breath test (13C UBT) for monitoring treatment efficacy.
  • To determine the prevalence of HP infection in children with nephrotic syndrome.

Main Methods:

  • A cohort of 20 children with nephrotic syndrome was studied.
  • Children were grouped based on prednisone treatment duration (1-3 months vs. >6 months).
  • Diagnostic methods included gastroscopy, histopathology, and 13C UBT before and after HP treatment.

Main Results:

  • Helicobacter pylori (HP) infection was detected in 65% of children with nephrotic syndrome.
  • HP infection prevalence was higher in children treated longer than 6 months (90%) compared to 1-3 months (40%).
  • HP infection treatment demonstrated 100% success, confirmed by 13C UBT.

Conclusions:

  • Children with nephrotic syndrome exhibit increased susceptibility to HP infection.
  • Effective treatment for HP infection is achievable in this pediatric population.
  • 13C UBT serves as a reliable non-invasive tool for assessing HP treatment efficacy.
Abstract

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