Developmental neuroimaging of children using magnetic resonance techniques

Cognitive and motor development in children remain fascinating processes that are uniquely human. Progress has been made in recent years in elucidating the prenatal process of human brain development. In addition, much information exists regarding the behavioral aspects of postnatal human development. However, little is known about the relationship between anatomic postnatal central nervous system development and the accretion of functional milestones observed in children from the neonatal period through adolescence. Recently, powerful qualitative and quantitative magnetic resonance techniques have been developed that will permit detailed inquiry into the connection between the developing brain and the developing mind. In this review, first, the steps of prenatal and postnatal brain development are reviewed briefly. Subsequently, recent magnetic resonance imaging data related to human brain development during the fetal, neonatal, and later childhood periods are presented. Finally, functional magnetic resonance imaging (fMRI) is discussed. Specific examples of its usefulness are provided. Magnetic resonance imaging techniques such as quantitative MRI, volumetric MRI, diffusion tensor imaging, and functional magnetic resonance imaging (fMRI) when combined with neurologic and neuropsychologic evaluation, will provide new insights into the cognitive development of children. MRDD Research Reviews 6:68-80, 2000.