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Published on: March 14, 2019
Mesigyna once-a-month combined injectable contraceptive: experience in Latin America
S Bassol1, M C Cravioto, M Durand
1Centro de Investigacion Biomedica Universidad, Autonoma de Coahuila, Mexico. sbassol@hotmail.com
Contraception
|July 25, 2000
Summary
This study shows Mesigyna, a monthly injectable contraceptive, is highly effective for Latin American women, with a 0% pregnancy rate. It offers good cycle control, though bleeding issues were noted in some users.
Area of Science:
- Reproductive Health
- Clinical Pharmacology
- Contraception
Background:
- Combined injectable contraceptives offer a reversible hormonal method for family planning.
- Assessing long-term efficacy and side effect profiles is crucial for contraceptive adoption.
Purpose of the Study:
- To evaluate the contraceptive efficacy, cycle control, and side effects of Mesigyna, a once-a-month injectable contraceptive.
- To assess the suitability of Mesigyna for Latin American women.
Main Methods:
- A phase III clinical study involving 534 fertile Latin American women.
- Data collected on pregnancy rates, discontinuation rates, bleeding patterns, and weight changes over one year.
Main Results:
- Zero pregnancies per 100 woman-years (95% CI 0-0.08) over 4688 woman-months of use.
- Overall discontinuation rate was 17.9% at one year; 5.1% due to bleeding problems (higher in Colombian women).
- Mean weight gain was 1.02 kg after one year; amenorrhea discontinuation was 1.1%.
Conclusions:
- Mesigyna is a highly effective once-a-month injectable contraceptive for Latin American women.
- Its efficacy and acceptable side effect profile, including menstrual bleeding perception, support its use in this population.
Keywords:
BiologyBleedingClinical ResearchContraceptionContraceptive AgentsContraceptive Agents, FemaleContraceptive Agents, ProgestinContraceptive EffectivenessContraceptive MethodsDeveloping CountriesDiseasesEndocrine SystemEstradiolEstrogensFamily PlanningHealthHormonesInjectablesLatin AmericaMenstruationNorethindroneNorethindrone EnanthatePhysiologyPublic HealthReproductionResearch MethodologyResearch ReportSafetySigns And Symptoms
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