[Use of rectal diazepam administration for control of epileptic seizures in children. A multicenter study]

Area of Science:

• Pediatric Neurology
• Emergency Medicine
• Clinical Pharmacology

Background:

• Prolonged convulsions and status epilepticus are medical emergencies in children.
• Prompt and effective seizure termination is crucial to prevent neurological damage.
• Rectal diazepam is a potential first-line treatment option.

Purpose of the Study:

• To evaluate the efficacy and safety of rectal diazepam administration using a rectal appliance.
• To assess the onset of action and success rate of this treatment in children.

Main Methods:

• A multicentre study involving 178 children with prolonged convulsions or status epilepticus.
• Rectal administration of diazepam via a specialized rectal appliance.
• Data collection on seizure termination, onset of action, and adverse events.

Main Results:

• Diazepam was effective in terminating seizures in 98% of the studied children.
• The treatment demonstrated a rapid onset of action.
• Rectal diazepam was found to be safe for pediatric use.

Conclusions:

• Rectal administration of diazepam via a rectal appliance is a highly effective and safe treatment for pediatric seizures.
• The rapid onset and high efficacy support its use across various medical settings.
• This method is suitable for administration by healthcare professionals and caregivers at home.