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[Deletion of MTS1/p16 gene in endometrial carcinoma]
1Cancer Institute, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing.
Objective:
To investigate the possible relationship between deletion of MTS1/p16 gene and progression of endometrial carcinoma.
Methods:
Thirty two primary endometrial carcinoma, 7 tumor-adjacent endometrial tissue and 10 normal endometrial tissue specimens were examined for homozygous deletion of MTS1/p16 gene by polymerase chain reaction-based analysis.
Results:
Of 32 endometrial cancer specimens, 6(18.8%) showed homozygous deletion of MTS1/p16 gene. No deletion was detected in the tumor-adjacent and normal endometrial tussues. Nor was it detected in well differentiated endometrial carcinoma.
Conclusions:
Deletion of MTS1/p16 gene might contribute to the progression of endometrial carcinoma and could be served as indicator for predicting prognosis.