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Updated: Aug 16, 2026

Laminar Flow-based Assays to Investigate Leukocyte Recruitment on Cultured Vascular Cells and Adherent Platelets
Published on: April 9, 2018
[Clinical observation on the adhesion molecule expression and functional study of platelets in cancer patients]
1Tumor Department, Guanganmen Hospital, China Academy of Traditional Chinese Medicine, Beijing.
Objective:
To investigate adhesion molecule expression and functional status of platelets in cancer patients and their relation to cancer progression.
Methods:
Using flow cytometry to measure the expression of surface antigens and functional status of platelets in 50 healthy donors and 181 cancer patients.
Results:
Comparing with normal donors, the expression of CD42a in cancer patients decreased, and that of TSP and CD36 increased. The number of platelets with CD36+ TSP+, CD36+ TSP-, CD9+, CD31+, CD62+ CD63-, CD62+ CD63+, CD62- CD63+ phenotypes also increased. There was significant difference between patients in early stage and those in advanced stage, but there was no significant difference between the patients in early stage and healthy donors. The expression of CD41 did not change in cancer patients.
Conclusion:
In cancer patients, especially in the advanced stage of the disease, the expression of the adhesion molecules on platelets and their released products increase, indicative of an activated state of the platelets.
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