[LIM homeobox genes family in nervous system]

Homeobox genes define a class of genes containing homeobox sequences and encoding proteins, that are identified as transcription regulator controlling cellular development and differentiation, and controlling patterns of gene expression. LIM homeobox genes contain both a homeobox and a conservative sequences (encoded LIM domain). The members of the LIM homeobox genes family which have recently been identified include lin-11, mec-3, apterous(ap), isl-1, LH-2, Rlim, lim-1, lmx-1, Xlim-1 and Xlim-3. Recent findings suggested that products expressed by LIM homeobox genes family play an important role in adjusting differentiation and developmental of the organism. The effects of LIM homeobox genes in the differentiation and development of neurons are currently attracting more and more attention.