[Role Ofhydrogen Sulfide on Inflammatory Immune Disorders in Cardiovascular Diseases]

Hydrogen sulfide (H2S),a colorless gas with a characteristic rotten-egg odor, has traditionally been considered to be a toxic environmental pollutant. Recently, a multitude of works have demonstrated that H2S was identified as the third gaseous signaling molecule alongside nitric oxide and carbon monoxide. Similar to other gaseous signaling molecules,H2S playeda pivotal role in the pathophysiological processes of cardiovascular disease due to its various biological activities, including anti-oxidative, antiapoptotic, proangiogenic, vasodilating capacities, modulating endothelial nitric oxide synthase activity, and so on. However, the mechanisms of H2S underlying the process remained unclear. In the present review, we summarized the current knowledge on the regulatory effects of H2S on disorders of immune inflammation in cardiovascular disease and underlying molecular mechanisms. A better understanding of the biochemical function of H2S might provide a new therapeutic strategy for cardiovascular diseases.