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New insecticidal bufadienolide, bryophyllin C, from Kalanchoe pinnata
U Supratman1, T Fujita, K Akiyama
1Department of Applied Biological Chemistry, College of Agriculture, Osaka Prefecture University, Sakai, Japan.
Bioscience, Biotechnology, and Biochemistry
|August 3, 2000
Abstract:
Two insecticidal bufadienolides (1 and 2) were isolated from a methanol extract of the leaves of Kalanchoe pinnata by bioassay-guided fractionation. Compound 1 was identified as known bryophyllin A (bryotoxin C). The structure of new bufadienolide 2, named bryophyllin C, was determined by spectroscopic methods and the chemical transformation of 1. Compounds 1 and 2 showed strong insecticidal activity against third instar larvae of the silkworm (Bombyx mori), their LD50 values being evaluated as 3 and 5 microg/g of diet, respectively.