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Small peptides Do not inhibit human non-pancreatic secretory phospholipase-A(2) (Type IIA)
C I Clark1, R C Reid, R P McGeary
1The Centre for Drug Design and Development, Institute for Molecular Bioscience, Brisbane, Queensland, 4072, Australia. c.clark@mailbox.up.edu.au
Biochemical and Biophysical Research Communications
|August 5, 2000
Abstract:
Seven small peptides, that are among the most potent reported inhibitors of secreted mammalian phospholipases A(2), were found not to inhibit processing of a small phospholipid substrate by human non-pancreatic secretory phospholipase A(2) (type IIa), under conditions where certain non-peptides are potent inhibitors at nanomolar concentrations.