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Topical ciprofloxacin for bacterial corneal ulcer
P Kosrirukvongs1, W Buranapongs
1Department of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Summary
Topical ciprofloxacin offers a viable alternative for treating bacterial corneal ulcers, showing comparable healing rates to standard treatments. This study suggests ciprofloxacin as a potential option for patients with moderate bacterial keratitis.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Pharmacology
Background:
- Bacterial corneal ulcers are a significant cause of vision loss.
- Effective antimicrobial therapy is crucial for managing bacterial keratitis.
Purpose of the Study:
- To evaluate the efficacy of topical ciprofloxacin compared to standard therapy for bacterial corneal ulcers.
- To assess treatment success rates and healing duration.
Main Methods:
- A randomized, controlled clinical trial was conducted.
- Patients with suspected bacterial corneal ulcers received either topical ciprofloxacin or cefazolin/gentamicin.
- Outcomes measured included therapeutic success and time to ulcer healing.
Main Results:
- Therapeutic success rates were similar between the ciprofloxacin (70.6%) and control (62.5%) groups.
- Mean healing durations were comparable: 15.6 days for ciprofloxacin and 14.6 days for the control group.
- Visual improvement was higher in the ciprofloxacin group (66.7%) compared to the control group (46.7%).
Conclusions:
- Topical ciprofloxacin is a potential alternative treatment for bacterial corneal ulcers.
- The study supports considering ciprofloxacin as part of standard care for bacterial keratitis.