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Occurrence of thyroid autoimmunity in relapsing remitting multiple sclerosis patients undergoing interferon-beta
V Martinelli1, M Gironi, M Rodegher
1Clinical Neurology Unit IV, University of Milan, Scientific Institute S. Raffaele, Italy.
Abstract:
We analyzed the titer of antithyroid autoantibodies (Abs) and thyroid function in 17 multiple sclerosis (MS) patients undergoing interferon-beta (IFN-beta) treatment and in 40 MS control patients. Basal evaluation revealed normal thyroid function in all patients. Abs were detected in 5 IFN-beta-treated patients (29%) and in 4 MS control patients (10%). Our results indicate that IFN-beta treatment may lead to thyroid autoimmunity. We therefore recommend periodic evaluations of antithyroid Abs and thyroid functionality in IFN-beta-treated MS patients.
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