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Intracardiac thrombus in Behçet's disease: a systematic review
N Mogulkoc1, M I Burgess, P W Bishop
1Department of Pulmonary Medicine, Ege University, Izmir, Turkey. 100046.1102@compuserve.com
Chest
|August 11, 2000
Summary
Intracardiac thrombus, a rare complication of Behçet's disease, often presents in young men from the Mediterranean and Middle East. Consider Behçet's disease in patients with right-sided cardiac masses, even without typical symptoms.
Area of Science:
- Cardiology
- Rheumatology
- Internal Medicine
Background:
- Behçet's disease is a rare systemic vasculitis with a predilection for the Silk Road regions.
- Intracardiac thrombus formation is an uncommon but severe complication of Behçet's disease.
Purpose of the Study:
- To review the clinical and pathological features of intracardiac thrombus in Behçet's disease patients.
- To identify risk factors and diagnostic clues for cardiac thrombus in Behçet's disease.
Main Methods:
- A comprehensive literature search was performed using MEDLINE.
- Analysis of clinical and pathological data from reported cases of intracardiac thrombus in Behçet's disease.
Main Results:
- Most reported cases originated from the Mediterranean basin and the Middle East.
- Young men are the most affected demographic, with the right heart being the most common site.
- Intracardiac thrombus was evident at initial disease presentation in over half of the cases.
Conclusions:
- Behçet's disease should be suspected in patients presenting with right-sided cardiac masses, especially young men from the Mediterranean/Middle East.
- Diagnosis is crucial even in the absence of classic Behçet's disease symptoms.
- Early consideration aids in timely management of this serious complication.