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Cellular function of p70S6K: a role in regulating cell motility
1Molecular Signalling Group, John Curtin School of Medical Research, Australian National University, Canberra. leise.berven@anu.edu.au
Immunology and Cell Biology
|August 18, 2000
Summary
The 70 kDa ribosomal S6 kinase (p70S6K) regulates protein synthesis and cell functions. New research suggests p70S6K also plays a key role in controlling cell motility, impacting processes like tumor metastasis and tissue repair.
Area of Science:
- Molecular Biology
- Cellular Biology
- Biochemistry
Background:
- The 70 kDa ribosomal S6 kinase (p70S6K) is a key enzyme activated by growth factors and hormones.
- p70S6K phosphorylates the 40S ribosomal protein S6, a critical component of the protein synthesis machinery in mammalian cells.
- p70S6K is known to regulate translation, cell cycle control, and neuronal differentiation.
Purpose of the Study:
- To review the known regulation and cellular functions of p70S6K.
- To propose and discuss a novel function of p70S6K in regulating cell motility.
- To highlight the potential implications of p70S6K in cell motility for various biological processes.
Main Methods:
- Literature review of existing research on p70S6K.
- Analysis of recent experimental data from the authors' laboratory.
- Synthesis of information to propose a new functional role.
Main Results:
- p70S6K activation involves phosphorylation at multiple sites.
- Activated p70S6K targets 40S ribosomal protein S6, impacting protein synthesis.
- Emerging evidence suggests p70S6K involvement in cell motility regulation.
Conclusions:
- p70S6K is a multifunctional kinase with established roles in translation and cell differentiation.
- p70S6K's role in cell motility is a novel area of investigation with significant implications.
- Understanding p70S6K's function in cell motility could impact research on cancer, immunity, and tissue repair.