Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bone cancers in Mayak workers.

N A Koshurnikova1, E S Gilbert, M Sokolnikov

  • 1Branch No. 1 of the State Scientific Center "Biophysics Institute", Ozyorsk, Chelyabinsk Region, Russia.

Radiation Research
|August 24, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Radiation Dose and Solid Cancer Mortality Risk in the Techa River and East Urals Radioactive Trace Cohorts in 1950-2016.

Radiation research·2025
Same author

[Analysis of hearing aids application in elderly patients.]

Advances in gerontology = Uspekhi gerontologii·2023
Same author

Comparison of All Solid Cancer Mortality and Incidence Dose-Response in the Life Span Study of Atomic Bomb Survivors, 1958-2009.

Radiation research·2022
Same author

ICRP Publication 150: Cancer Risks from Plutonium and Uranium Exposure.

Annals of the ICRP·2021
Same author

Fluorescence imaging of cells using long-range electromagnetic surface waves for excitation.

Applied optics·2020
Same author

The radiological environment at the Mayak PA site and radiation doses to individuals involved in emergency and remediation operations after the 'Kyshtym Accident' in 1957.

Journal of radiological protection : official journal of the Society for Radiological Protection·2020
Same journal

KRT6A Impairs Radiosensitivity in Cervical Squamous Cell Carcinoma by Enhancing Fatty Acid Synthesis.

Radiation research·2026
Same journal

Chromosomal Instability: A Potential Biomarker of Radiation Response.

Radiation research·2026
Same journal

Antioxidant Probucol Reduces Mortality in Mice Exposed to Lethal Doses of Ionizing Radiation.

Radiation research·2026
Same journal

The Detection of Radiation Effects in the Urine of Rhesus Macaques Using Raman Spectroscopy.

Radiation research·2026
Same journal

Characterization of Radiation-responsive Genes and Transcript Variants under Different Radiation Qualities, Doses and Dose Rates.

Radiation research·2026
Same journal

Methyl Quercetin Inhibits Radiation-induced Senescence and TGF-β1-induced Myofibroblast Differentiation Through Psmad3/TGF-Β Signaling.

Radiation research·2026
See all related articles

Bone cancer mortality risks increased for Mayak workers exposed to plutonium and gamma radiation. Higher risks were observed in females, plutonium plant workers, and those with higher plutonium body burdens.

Area of Science:

  • Occupational Health
  • Radiation Epidemiology
  • Nuclear Worker Safety

Background:

  • The Mayak Production Association employed workers exposed to internal plutonium and external gamma radiation.
  • Previous studies indicated potential health risks associated with these exposures.

Purpose of the Study:

  • To evaluate bone cancer mortality risks in Mayak workers exposed to plutonium and gamma radiation.
  • To assess the relationship between plutonium body burden and bone cancer mortality.
  • To compare mortality rates with general population data.

Main Methods:

  • Retrospective cohort study of 11,000 Mayak workers (1948-1958).
  • Analysis of mortality data, comparing Mayak workers to Russian and U.S. general populations.
  • Internal dose estimation for plutonium body burden and external dose assessment for gamma radiation.

Related Experiment Videos

  • Statistical analysis to determine relative risks and confidence intervals.

    • Main Results:

    • Excess bone cancer mortality was observed in the Mayak worker cohort compared to general populations, particularly among females and plutonium plant workers.
    • Workers with estimated plutonium body burdens exceeding 7.4 kBq showed a significantly increased risk (relative risk = 7.9).
    • Increased mortality risk was also associated with lack of routine plutonium monitoring and higher cumulative external doses (>1 Sv).
    • A continuous increase in bone cancer risk was correlated with increasing plutonium body burden (P < 0.001).

    Conclusions:

    • Internal plutonium deposition is a significant risk factor for bone cancer mortality in Mayak workers.
    • Occupational radiation exposure at Mayak poses a substantial bone cancer risk, especially with higher plutonium body burdens.
    • Limitations in current plutonium dosimetry prevent precise risk quantification in terms of organ dose.