Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Basal cell carcinoma.

S Ramachandran1, A A Fryer, A G Smith

  • 1Centre for Cell and Molecular Medicine, School of Postgraduate Medicine, North Staffordshire Hospital, Keele University, Staffordshire, England.

Cancer
|August 30, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

People with Type Diabetes Mellitus (T1DM) self-reported views on their own condition management reveal links to potentially improved outcomes and potential areas for service improvement.

Diabetes research and clinical practice·2020
Same author

The association of sex hormone-binding globulin with mortality is mediated by age and testosterone in men with type 2 diabetes.

Andrology·2018
Same author

Are cholesterol levels being checked and managed appropriately in UK primary care type 2 diabetes?

International journal of clinical practice·2015
Same author

Measuring vitamin D levels: surrogates are insufficient.

International journal of clinical practice·2014
Same author

Predicting dysglycaemia in patients under investigation for acute coronary syndrome.

QJM : monthly journal of the Association of Physicians·2010
Same author

The rise and fall of C-reactive protein: managing demand within clinical biochemistry.

Annals of clinical biochemistry·2009
Same journal

Toward exercise as standard care for older cancer survivors.

Cancer·2026
Same journal

Maintenance therapy in gynecologic malignancies: Current and future state.

Cancer·2026
Same journal

Long-term outcomes of evolving treatment regimens in Ewing sarcoma survivors diagnosed 1970-1999: A report from the Childhood Cancer Survivor Study.

Cancer·2026
Same journal

Large-scale osteosarcoma sequencing reveals age-associated genomic architectures.

Cancer·2026
Same journal

EZH2 inhibitor tazemetostat voluntarily withdrawn from market.

Cancer·2026
Same journal

Nivolumab and chemotherapy combination approved for previously untreated Hodgkin lymphoma.

Cancer·2026
See all related articles

Basal cell carcinoma (BCC) clusters are a late event, signaling increased tumor growth. Identifying BCC clusters is crucial for understanding disease progression and patient outcomes.

Area of Science:

  • Dermatology
  • Oncology
  • Genetics

Background:

  • Basal cell carcinoma (BCC) exhibits significant variation in tumor development among patients.
  • Previous research indicated that a cluster of BCCs suggests an inherited predisposition to developing numerous lesions.
  • A BCC cluster is defined as two or more new, primary BCCs appearing at initial or subsequent presentations.

Purpose of the Study:

  • To determine if BCC clustering is an early or late event in disease progression.
  • To assess whether tumor accrual is altered following the development of a BCC cluster.

Main Methods:

  • Recruited 927 patients diagnosed with basal cell carcinoma.
  • Analyzed patient data to categorize presentations into single lesion or cluster phenotypes.

Related Experiment Videos

  • Compared tumor accrual rates before and after cluster presentation.

    • Main Results:

    • Clustering of BCCs was identified as a relatively late event, with mean ages at cluster presentation being significantly later than initial single lesion presentations.
    • Patients presenting with BCC clusters showed a significantly increased rate of new tumor development post-clustering (1.99 BCC/year) compared to pre-cluster rates (0.39 BCC/year).
    • The single presentation phenotype (SPP)-more and multiple presentation phenotype (MPP)-cluster later groups had similar mean ages at first presentation with one BCC.

    Conclusions:

    • BCC cluster formation is a critical event associated with a significant increase in subsequent tumor accrual.
    • The late occurrence of BCC clusters suggests a potential decline in immune surveillance effectiveness.
    • Identifying BCC clusters aids in predicting disease progression and understanding underlying genetic predispositions.