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Diastereoselective synthesis of 3,4-dimethoxy-7-morphinanone: a potential route to morphine
1Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-8578, Japan.
Organic Letters
|August 31, 2000
Abstract:
[reaction: see text] Diastereoselective synthesis of racemic 3,4-dimethoxy-7-morphinanone from racemic 2-(2,3-dimethoxyphenyl)cyclohexen-1-ol has been achieved. The relative structure has been determined by transformation of the product into the known 3, 4-dimethoxy-6-morphinanone. Resolution of the starting cyclohexenol has also been accomplished for use in a future enantiocontrolled synthesis of morphine.