[Effect of hyperlipoproteinemia on blood fibrinolytic activity and thrombocyte aggregation]

An impaired lipid metabolism and macrovascular disease are often associated with diabetes mellitus. Effects of hyperlipoproteinemia on fibrinolytic blood activity and platelet aggregation were investigated in noninsulin-dependent diabetes mellitus.

The study sample consisted of 50 patients with noninsulin-dependent diabetes mellitus, only on dietetic regime. The following was studied: lipids (total cholesterol, HDL cholesterol and total triglycerides) fibrinolytic blood activity and platelet aggregation in patients with increased levels of cholesterol and triglycerides. We used enzymatic methods for lipids, Buckell's method for fibrinolysis (> 180 min) and Crean's method for platelet aggregation (6-8 s).

Statistical analysis of the obtained results shows significant changes in lipids. Triglycerides were significantly higher in diabetics with poor control (p < 0.01). Total cholesterol was significantly higher in patients with coronary disease, hypertension and diabetics with occlusive disease of low extremities (p < 0.01). HDL cholesterol was significantly lower in diabetics with coronary heart disease (p < 0.05). Statistical analysis showed significant changes in blood coagulability. Decreased fibrinolytic blood activity (158.10 + 31.3 min v.s. 169.82 + 21.05 min) (p < 0.05), as well as faster platelet aggregation (6.7 + 0.48 sec v.s. 6.8 + 0.93 sec) (p < 0.1) in patients with hypertriglyceridemia compared with the diabetics with normal triglycerides. Other lipids did not influence significantly the fibrinolysis and platelet aggregation in noninsulin-dependent diabetics.

All of this indicates the importance of the studied factors in the onset of atherosclerosis with patients with noninsulin-dependent diabetes; the latter is relevant to the importance of planned diabetic regime and moderate physical activity in preventing vascular complications of diabetes.