[Predictive factor for TESE (testicular sperm extraction)--ICSI (intracytoplasmic sperm injection) for...

Area of Science:

• Reproductive Medicine
• Andrology
• Infertility Treatment

Context:

• Non-obstructive azoospermia presents a significant challenge in male infertility.
• Testicular Sperm Extraction with Intracytoplasmic Sperm Injection (TESE-ICSI) offers a potential solution for sperm retrieval.
• The precise indications and predictive factors for TESE-ICSI success require further elucidation.

Purpose:

• To retrospectively analyze parameters predicting successful testicular sperm retrieval in patients with non-obstructive azoospermia.
• To evaluate the outcomes of Intracytoplasmic Sperm Injection (ICSI) following TESE.
• To identify clinical and histological factors influencing sperm recovery and fertilization rates.

Summary:

• A retrospective study of 44 patients with non-obstructive azoospermia undergoing TESE-ICSI was conducted.
• Sperm retrieval was successful in 72.7% of patients, with a 46.9% pregnancy rate among those undergoing ICSI.
• Testicular volume, Johnsen's score, and FSH levels were significant predictors of sperm retrieval, though not in cases with low Johnsen's scores. Partner's age, sperm motility, and testicular volume correlated with fertilization.

Impact:

• This study suggests that TESE-ICSI is a broadly applicable treatment for non-obstructive azoospermia.
• While no single parameter guarantees success, several factors can guide patient selection and counseling.
• The findings contribute to optimizing TESE-ICSI protocols and improving outcomes for infertile men.