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Sex-dependent electrocardiographic pattern of cardiac repolarization
H Bidoggia1, J P Maciel, N Capalozza
1Facultad de Medicina, Universidad del Salvador, Buenos Aires, Argentina.
American Heart Journal
|August 31, 2000
Summary
Sex differences in cardiac repolarization are significant. The J point and ST angle, reflecting early repolarization duration and rate, are key determinants of these electrocardiogram (ECG) patterns in men versus women.
Area of Science:
- Cardiology
- Physiology
- Electrocardiography
Background:
- Sex-dependent differences in cardiac repolarization are well-established.
- Limited research has quantified the contribution of individual electrocardiogram (ECG) repolarization variables to these sex differences.
Purpose of the Study:
- To identify specific ECG repolarization variables that contribute to sex-dependent patterns.
- To analyze the duration and rate of cardiac repolarization in relation to sex and age.
Main Methods:
- Analysis of multiple ECG repolarization variables in 500 healthy adults (250 men, 250 women) aged 20-80 years.
- Measurements taken from the precordial lead with the highest T-wave amplitude.
- Nonlinear (logistic) multivariate regression analysis to determine variable contribution.
Main Results:
- Cardiac repolarization was significantly shorter and faster in men compared to women (P <.001).
- The J point and ST angle demonstrated the highest individual weight in defining these sex differences.
- Analysis included variables reflecting both repolarization duration and rate.
Conclusions:
- Changes in early repolarization duration and rate are key determinants of sex-dependent ECG patterns.
- Specific ECG parameters, notably the J point and ST angle, underlie observed sex differences in cardiac repolarization.