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A mouse phenome project.

K Paigen1, J T Eppig

  • 1The Jackson Laboratory, Bar Harbor, Maine 04609, USA.

Mammalian Genome : Official Journal of the International Mammalian Genome Society
|September 1, 2000
PubMed
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This study established baseline phenotypic data for common mouse strains. The information is now available in a public database for researchers.

Area of Science:

  • * Genetics and Genomics
  • * Animal Models
  • * Phenotyping

Background:

  • * Inbred mouse strains are crucial models in biomedical research.
  • * Standardized phenotypic data is essential for reproducible studies.
  • * Genomic diversity among mouse strains impacts research outcomes.

Purpose of the Study:

  • * To create a comprehensive, community-driven resource of mouse strain phenotypic data.
  • * To establish baseline phenotypic profiles for widely used inbred mouse strains.
  • * To ensure data accessibility for the broader scientific community.

Main Methods:

  • * Community-wide collaborative effort involving multiple research institutions.
  • * Systematic collection and curation of phenotypic data across diverse mouse strains.

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  • * Development of a publicly accessible online database for data dissemination.

    • Main Results:

    • * Established baseline phenotypic data for numerous inbred mouse strains.
    • * Successfully launched a publicly accessible database housing this information.
    • * Facilitated data sharing and comparison across different mouse models.

    Conclusions:

    • * The established database serves as a valuable resource for mouse model selection and research design.
    • * This initiative promotes standardization and enhances the reproducibility of studies using inbred mouse strains.
    • * Accessible phenotypic data empowers researchers to better understand genotype-phenotype relationships.