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Interactions between liposomes and hydroxypropylmethylcellulose.

C Gutiérrez de Rubalcava1, J L Rodriguez, R Duro

  • 1Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad de Santiago de Compostela, Campus Universitario Sur, 15706, Santiago de Compostela, Spain.

International Journal of Pharmaceutics
|September 1, 2000
PubMed
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The adsorption of hydroxypropylmethylcellulose (HPMC) onto liposomes is influenced by cholesterol content. The polymer

Area of Science:

  • * Pharmaceutical Sciences
  • * Colloid and Surface Chemistry

Background:

  • * Liposomes are versatile drug delivery systems.
  • * Hydroxypropylmethylcellulose (HPMC) is a common pharmaceutical excipient.
  • * Understanding polymer-liposome interactions is crucial for formulation development.

Purpose of the Study:

  • * To investigate the adsorption mechanisms of HPMC onto liposomes.
  • * To determine the influence of cholesterol on HPMC adsorption.
  • * To analyze the conformational changes and hydration properties of adsorbed HPMC.

Main Methods:

  • * Preparation of liposomes with varying egg lecithin-cholesterol molar ratios.
  • * Adsorption isotherm studies to analyze HPMC incorporation.
  • * Langmuir model fitting for cholesterol-free liposomes.

Related Experiment Videos

  • * Analysis of apparent volumes and hydration enthalpy of adsorbed HPMC.

    • Main Results:

    • * Adsorption mechanisms varied with liposome composition, driven by hydrophobic interactions.
    • * Langmuir model fitted cholesterol-free liposome adsorption; sigmoidal slopes observed with cholesterol.
    • * Apparent volumes indicated HPMC conformation depends on liposome composition.
    • * Freeze-dried systems with adsorbed HPMC did not become more hydrophilic than expected.

    Conclusions:

    • * Cholesterol significantly alters HPMC adsorption mechanisms and kinetics onto liposomes.
    • * Liposome composition dictates HPMC conformation and interfacial behavior.
    • * The hydrophilic nature of HPMC did not translate to increased system hydrophilicity post-freeze-drying.