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Use of spoligotype analysis to detect laboratory cross-contamination
B Nivin1, J Driscoll, T Glaser
1New York City Department of Health, Tuberculosis Control Program, New York 10007, USA.
Infection Control and Hospital Epidemiology
|September 1, 2000
Abstract:
Spoligotype analysis identified false-positive isolates of Mycobacterium tuberculosis caused by laboratory cross-contamination. Spoligotyping is faster, is less expensive than DNA fingerprinting, and can be used with a variety of media. Patients were reevaluated and had medications discontinued as a result of this investigation. Months of unnecessary patient follow-up and treatment were avoided.