Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Conserved noncoding sequences are reliable guides to regulatory elements.

R C Hardison1

  • 1Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA. rch8@psu.edu

Trends in Genetics : TIG
|September 6, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exponential decay of GC content detected by strand-symmetric substitution rates influences the evolution of isochore structure.

Molecular biology and evolution·2007
Same author

Global predictions and tests of erythroid regulatory regions.

Cold Spring Harbor symposia on quantitative biology·2004
Same author

Association between divergence and interspersed repeats in mammalian noncoding genomic DNA.

Proceedings of the National Academy of Sciences of the United States of America·2001
Same author

Databases of human hemoglobin variants and other resources at the globin gene server.

Hemoglobin·2001
Same author

Sequences flanking hypersensitive sites of the beta-globin locus control region are required for synergistic enhancement.

Molecular and cellular biology·2001
Same author

New views of evolution and regulation of vertebrate beta-like globin gene clusters from an orphaned gene in marsupials.

Proceedings of the National Academy of Sciences of the United States of America·2001
Same journal

Beyond housekeeping: snRNA diversity, regulation, and human disease.

Trends in genetics : TIG·2026
Same journal

Rethinking mitochondrial metabolism: Intraindividual variability meets population constraints.

Trends in genetics : TIG·2026
Same journal

A role for epigenetics in rapid adaptation.

Trends in genetics : TIG·2026
Same journal

The myth of asexual fungi.

Trends in genetics : TIG·2026
Same journal

Rethinking molecular evolution through protein language model embeddings.

Trends in genetics : TIG·2026
Same journal

Co-transcriptional splicing: Distinct phases, mutual benefits, and basis for nuclear architecture.

Trends in genetics : TIG·2026
See all related articles

A draft of the human genome sequence is available. Comparing it with other species aids in identifying functional noncoding DNA segments, but the best species varies by location.

Area of Science:

  • Genomics
  • Comparative Genomics
  • Bioinformatics

Background:

  • The human genome sequence is now accessible as a working draft.
  • Identifying functional elements within noncoding DNA is crucial for understanding gene regulation.

Purpose of the Study:

  • To explore the utility of comparative genomics for identifying functional segments in the human genome.
  • To highlight the importance of selecting appropriate species for cross-species sequence comparisons.

Main Methods:

  • Comparative sequence analysis between human and other species (e.g., mouse).
  • Bioinformatic approaches to identify conserved noncoding elements.

Main Results:

  • Cross-species genome comparisons are effective for pinpointing functional noncoding regions, including gene regulatory elements.

Related Experiment Videos

  • The optimal species for comparison is locus-dependent, meaning it varies across different parts of the genome.

    • Conclusions:

    • Comparative genomics is a powerful tool for functional annotation of the human genome.
    • Strategic selection of species for comparative analysis is essential for maximizing discovery of regulatory elements.