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Examining noise sources at the single-molecule level: 1/f noise of an open maltoporin channel
1Laboratory of Physical and Structural Biology, NICHD, NIH, Bethesda, Maryland 20892-0924, USA.
Abstract:
We have studied the phenomenological origin of 1/f noise in a solute-specific bacterial ion channel, maltoporin. We show that after excision of small, but resolvable stepwise changes in the recordings of the current through a single open channel, the 1/f noise component disappears and the channel exhibits noise that is "white" below 100 Hz. Combined with results of a recent noise study of several bacterial porins, our observations suggest that 1/f noise is caused by the equilibrium conductance fluctuations related to the conformational flexibility of the channel pore structural constituents.
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