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[Decrease in circulating androgens in men during senescence].

R P Saucedo1, M E Fonseca, L Basurto

  • 1Unidad de Investigación en Enfermedades Endocrinas, Hospital de Especialidades, Instituto Mexicano del Seguro Social, México D.F.

Gaceta Medica De Mexico
|September 19, 2000
PubMed
Summary
This summary is machine-generated.

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Aging men experience a significant decline in key androgens like testosterone and dehydroepiandrosterone sulfate, alongside hormonal shifts including increased gonadotropins. These findings confirm age-related hormonal changes in men.

Area of Science:

  • Endocrinology
  • Andrology
  • Gerontology

Background:

  • Circulating androgen levels in aging men have conflicting reports.
  • Understanding these hormonal changes is crucial for men's health.
  • Age-related endocrine shifts require further investigation.

Purpose of the Study:

  • To descriptively analyze serum androgen levels in older men (60-70 years).
  • To compare these levels with those in younger men (20-44 years).
  • To investigate the impact of aging on a comprehensive panel of hormones.

Main Methods:

  • Descriptive study comparing two age groups of men.
  • Serum measurements included testosterone (T), dehydroepiandrosterone sulfate (DHEA-S), LH, FSH, estradiol (E), ACTH, prolactin (PRL), IGF-1, and SHBG.

Related Experiment Videos

  • Statistical analysis to identify significant differences between groups.

    • Main Results:

    • Older men showed significantly lower levels of testosterone (T), dehydroepiandrosterone sulfate (DHEA-S), and estradiol (E).
    • Elevated levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) were observed in older men.
    • Prolactin (PRL) and IGF-1 levels decreased with aging, while ACTH and SHBG remained unchanged.

    Conclusions:

    • Aging in men is associated with a significant decrease in circulating androgens from both gonadal and adrenal origins.
    • The observed increase in gonadotropins suggests a potential feedback mechanism related to declining androgens.
    • Future research will explore testosterone replacement therapy in aging men.