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Related Experiment Videos

Risperidone augmentation in refractory obsessive-compulsive disorder: an open-label study.

C Pfanner1, D Marazziti, L Dell'Osso

  • 1Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Italy.

International Clinical Psychopharmacology
|September 19, 2000
PubMed
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Adding risperidone to serotonin reuptake inhibitors (SRIs) effectively reduced obsessive-compulsive disorder (OCD) symptoms in treatment-resistant patients. This augmentation strategy showed promising results with manageable side effects in an open-label trial.

Area of Science:

  • Psychiatry
  • Clinical Pharmacology

Background:

  • Obsessive-compulsive disorder (OCD) is a debilitating mental health condition.
  • Treatment-resistant OCD often requires augmentation strategies.
  • Serotonin reuptake inhibitors (SRIs) are first-line treatments but may not be effective for all patients.

Purpose of the Study:

  • To evaluate the efficacy and tolerability of risperidone as an augmentation agent for SRI-refractory OCD.
  • To assess the impact of risperidone on obsessive-compulsive symptoms in patients with comorbid conditions.

Main Methods:

  • An open-label trial involving 20 outpatients with refractory OCD.
  • Patients received a SRI for at least 6 months without adequate response.
  • Risperidone was added and titrated to a mean dose of 3 mg/day over 8 weeks.

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Main Results:

  • All 20 patients demonstrated a reduction in obsessive-compulsive symptoms.
  • Symptom reduction was particularly notable in patients with comorbid bipolar disorder.
  • Mild side effects including sedation, postural hypotension, tremors, and increased appetite were reported by a minority of patients and were well-tolerated.

Conclusions:

  • Augmentation with risperidone is a potentially effective strategy for enhancing SRI treatment in refractory OCD.
  • The combination therapy was generally well-tolerated, with no treatment discontinuations due to adverse events.