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Related Experiment Videos

Radioactivity in breast milk following 111In-octreotide.

F P Castronovo1, H Stone, J Ulanski

  • 1Department of Radiology, Nuclear Medicine, Brigham and Women's Hospital, Boston, MA 02115-6110, USA.

Nuclear Medicine Communications
|September 20, 2000
PubMed
Summary

Indium-111 octreotide (OctreoScan) in breast milk decreases bi-exponentially after maternal injection. Nursing infants receive low radiation doses, with potential for even lower exposure due to poor oral absorption.

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Area of Science:

  • Nuclear Medicine
  • Radiopharmacology
  • Pediatric Dosimetry

Background:

  • Assessing radiation exposure to nursing infants is crucial for safe diagnostic imaging during lactation.
  • Indium-111 octreotide (OctreoScan) is used for imaging neuroendocrine tumors, and its excretion into breast milk requires evaluation.

Observation:

  • 111In concentration in breast milk and external breast surface radiation followed a bi-exponential decay pattern post-injection.
  • Maximum breast milk concentration was observed at 4 hours, with rapid decrease attributed to urinary excretion.

Findings:

  • Calculated internal and external dose equivalents for a 10-day nursing period were 22.97 mrem and 27.86 mrem, respectively.
  • The total estimated dose to the infant was 50.83 mrem, with significantly lower doses on day 10.

Related Experiment Videos

  • Poor oral absorption of indium (approx. 0.15%) suggests actual infant dose may be considerably lower than calculated.

    • Implications:

    • Provides a conservative dosimetry model for nursing infants exposed to 111In-octreotide.
    • Mathematical relationships are presented to estimate infant dose equivalents based on maternal administration time.
    • Supports informed clinical decisions regarding breastfeeding after OctreoScan administration.