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Updated: Aug 8, 2026

Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells
Published on: April 16, 2012
T-cell lineage fate: instructed by receptor signals?
1Harvard Medical School, Dana-Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115, USA. harald_von_boehmer@dfci.harvard.edu
Abstract:
Mechanisms of lineage choice represent a challenging problem in developmental biology. Recent studies have shown that different T-cell receptor signals can affect CD4 or CD8 lineage choice. Thus, all the ingredients for instructive mechanisms of lineage fate are in place but other mechanisms cannot be completely ruled out.
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