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Studies of the cardiovascular effects of nociceptin and related peptides
M B Salis1, C Emanueli, A F Milia
1National Laboratory of the National Institute of Biostructures and Biosystems, Osilo, Italy.
Peptides
|September 22, 2000
Abstract:
Nociceptin, a novel opioid peptide, and its ORL(1) receptor share structural similarities with other opioid ligands and receptors. Although NC exerts evident cardiovascular effects at a central and peripheral level, its role in homeostatic mechanisms and disease states are just beginning to be understood, as only recently selective receptor antagonists became available. In this review, some of the new observations regarding the cardiovascular actions of NC, related peptides and newly synthesized receptor antagonists are discussed.