Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

False-negative diffusion-weighted MR findings in acute ischemic stroke.

C Oppenheim1, R Stanescu, D Dormont

  • 1Department of Neuroradiology, Groupe Hospitalier Pitié-Salpêtrière, Paris VI University, France.

AJNR. American Journal of Neuroradiology
|September 26, 2000
PubMed
Summary

Diffusion-weighted imaging (DWI) can miss acute ischemic stroke lesions, especially in the posterior circulation within 24 hours. Persistent symptoms warrant further investigation despite negative early DWI results.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hippocampal microstructural changes following electroconvulsive therapy in severe depression.

Molecular psychiatry·2025
Same author

FLAIR Vascular Hyperintensities as a Surrogate of Collaterals in Acute Stroke: DWI Matters.

AJNR. American journal of neuroradiology·2022
Same author

Spinal epidural capillary hemangioma: A systematic literature review and an illustrative case.

Neuro-Chirurgie·2022
Same author

Clot Burden Score and Collateral Status and Their Impact on Functional Outcome in Acute Ischemic Stroke.

AJNR. American journal of neuroradiology·2020
Same author

Benefit of first-pass complete reperfusion in thrombectomy is mediated by limited infarct growth.

European journal of neurology·2020
Same author

Anatomical and functional MR imaging to define tumoral boundaries and characterize lesions in neuro-oncology.

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique·2020

Area of Science:

  • Neurology
  • Radiology
  • Medical Imaging

Background:

  • Diffusion-weighted imaging (DWI) is crucial for detecting acute ischemic stroke.
  • Concerns exist regarding DWI's sensitivity in identifying all acute stroke lesions.
  • False-negative DWI findings can delay diagnosis and treatment.

Purpose of the Study:

  • To estimate the rate of false-negative DWI studies in patients with persistent neurologic deficits.
  • To identify specific stroke lesion characteristics missed by DWI.

Main Methods:

  • Retrospective review of MRI scans within 48 hours of stroke onset in 139 patients.
  • Analysis of cases with initially negative DWI but positive follow-up imaging.
  • Evaluation of lesion size, vascular territory, and timing of DWI acquisition.

Related Experiment Videos

Main Results:

  • 5.8% of initial DWI studies were false-negative.
  • False-negative rates were higher for posterior circulation strokes (19%) vs. anterior (2%).
  • 31% of vertebrobasilar strokes had false-negative DWI within 24 hours, often in the brain stem.

Conclusions:

  • False-negative DWI is not rare in the early hours of ischemic stroke.
  • Vertebrobasilar strokes, particularly in the brain stem, are prone to false-negative DWI.
  • Persistent symptoms suggestive of stroke necessitate considering DWI-negative cases, especially early on.