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Reproducibility of intracortical inhibition and facilitation using the paired-pulse paradigm
B Boroojerdi1, L Kopylev, F Battaglia
1Human Cortical Physiology Section, National Institute of Neurological Disorders and Stroke, Building 10, Room 5N 234, National Institutes of Health, 10 Center Drive, MSC 1428, Bethesda, Maryland 20892-1428, USA.
Abstract:
We have evaluated the reproducibility of intracortical inhibition (ICI) and facilitation (ICF) studied with paired-pulse focal transcranial magnetic stimulation. Three investigators studied the same subjects (n = 4) in three different sessions. A high variability was shown across subjects [coefficient of variation, (cv) 67.3% for ICI and 21.2% for ICF]. Intersession variability was up to 37.1% for ICI and 22.7% for ICF. Interinvestigator variability was 17.3% for ICI and negligible for ICF. Our results may have implications for planning future studies.