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Pyoderma gangrenosum and myelodysplastic syndrome
D Litvak1, R S Kirsner, N N Pakdaman
1Department of Medicine, Yale University School of Medicine, New Haven, Conn, USA.
Southern Medical Journal
|September 27, 2000
Summary
Pyoderma gangrenosum (PG) is a painful skin disorder. Patients with PG and unexplained anemia should undergo bone marrow biopsy to check for myelodysplastic syndromes.
Area of Science:
- Dermatology
- Hematology
- Oncology
Background:
- Pyoderma gangrenosum (PG) is an inflammatory skin condition often linked to systemic diseases.
- Anemia is a common comorbidity in patients with pyoderma gangrenosum.
Observation:
- This report details a patient presenting with pyoderma gangrenosum and concurrent anemia.
- The patient's clinical presentation prompted further investigation into the underlying cause of the anemia.
Findings:
- A bone marrow biopsy revealed findings consistent with myelodysplastic syndromes, specifically refractory anemia with ringed sideroblasts.
- This suggests a potential link between myelodysplastic syndromes and pyoderma gangrenosum in this case.
Implications:
- Bone marrow biopsy is a crucial diagnostic tool for patients with pyoderma gangrenosum and unexplained anemia.
- Early diagnosis of myelodysplastic syndromes can lead to timely management and potentially improve patient outcomes.