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Escape mechanisms in tumor immunity: a year 2000 update
G Pawelec1, S Heinzel, R Kiessling
1Section for Transplantation Immunology, University of Tübingen, Germany. graham.pawelec@uni-tuebingen.de
Critical Reviews in Oncogenesis
|September 27, 2000
Summary
Most tumors are immunogenic and express antigens. This review details tumor immune evasion strategies, updating knowledge on how cancers evade the host immune system.
Area of Science:
- Immunology
- Oncology
- Cancer Research
Background:
- Most tumors are recognized as immunogenic, expressing antigens that the host immune system can detect.
- Tumor progression necessitates the evolution of strategies to evade immune responses.
- This review updates a 1997 publication, focusing on advancements in understanding tumor immune evasion.
Purpose of the Study:
- To review the current knowledge on tumor immune evasion strategies.
- To highlight the significant accumulation of new data in this field since 1997.
- To emphasize the growing importance of studying tumor escape from immune surveillance.
Main Methods:
- Literature review focusing on publications since 1997.
- Synthesis of current understanding of tumor immune evasion mechanisms.
- Comparative analysis with previous findings from 1997.
Main Results:
- Tumors employ diverse strategies to evade immune detection and destruction.
- Significant progress has been made in identifying and characterizing these evasion mechanisms.
- The field has seen an "impressive accumulation of new data" since the last review.
Conclusions:
- Understanding tumor immune evasion is crucial for developing effective cancer immunotherapies.
- Continued research into tumor escape strategies is vital for advancing cancer treatment.
- The immune system's role in cancer progression and treatment is a dynamic and evolving area of study.