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Updated: Jul 15, 2026

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
[Effects of significantly increased perinatal risks on developmental status in adolescence]
A Bäcker1, U Pauli-Pott, G Neuhäuser
1Zentrum für Psychosomatische Medizin, Abteilung Medizinische Psychologie, Giessen.
Abstract:
In a 13-years-catamnesis a sample of 50 children with severe perinatal risks was assessed with regard to their physical, cognitive and behavioral development; selective drop-outs were analysed. In accordance with the results of other prospective studies there are deficits in visual-motor functioning, higher rates of somatic complaints, social withdrawal and attention deficits; a large number of these children attend special schools. The study presents predicative relations between risk factors of birth-time and the developmental status at youth. In comparison with typical single risks (e.g. gestational age or respiratory distress syndrome) a complex index for the perinatal risk, the so-called birth-optimality offers no substantial advantage. A significant influence of social factors is shown for school achievement. Children of fathers with higher educational level are attending schools of a higher grade. The combination of biological and social factors improves the reliability of developmental prognosis; the Mental Developmental Index of the Bayley Scales of Infant Development provides additional prognostic accuracy. For compensating developmental disadvantages especially parents with lower educational level should be informed about beneficial care. Even children of these families, who scored low in early cognitive assessments should receive early intervention or therapeutic support.
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