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A facile synthesis of dragmacidin B and 2,5-bis(6'-bromo-3'-indolyl)piperazine
F Y Miyake1, K Yakushijin, D A Horne
1Department of Chemistry, Oregon State University, Corvallis, Oregon 97331, USA.
Organic Letters
|September 29, 2000
Abstract:
A short synthesis of dragmacidin B (1), 2,5-bis(6'-bromo-3'-indolyl)piperazine (2), and corresponding didebromo analogues 8 and 9 is described. The key steps involve the dimerization of oxotryptamines 4 and 11 to give bis(indolyl)pyrazines 5 and 12, which upon selective reduction and reductive methylation with sodium cyanoborohydride afforded the requisite piperazine natural products.