Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Statistical properties of thermodynamic quantities for cyclodextrin complex formation.

R R Burnette1, K A Connors

  • 1School of Pharmacy, University of Wisconsin, 425 N. Charter Street, Madison, Wisconsin 53706, USA.

Journal of Pharmaceutical Sciences
|October 4, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparisons of PNEC derivation logic flows under example regulatory schemes and implications for ecoTTC.

Regulatory toxicology and pharmacology : RTP·2021
Same author

Aromatic hydroxylation as an analytical reaction.

Analytical chemistry·2012
Same author

Binding of substituted acetic acids to alpha-cyclodextrin in aqueous solution.

Journal of pharmaceutical sciences·1997
Same author

Characterization of the effects of amphotericin B on ion channels in MDCK cells using the patch-clamp technique.

Biochimica et biophysica acta·1997
Same author

Binding of cyclodextrins to alicyclic and aromatic substrates: complex formation of alpha-, beta-, and gamma-cyclodextrins with substituted cyclohexanecarboxylic acids and phenylalkanoic acids.

Journal of pharmaceutical sciences·1997
Same author

Computer simulation of human blood flow and vascular resistance.

Computers in biology and medicine·1996
Same journal

Immune tolerance platforms to mitigate unwanted immune responses.

Journal of pharmaceutical sciences·2026
Same journal

Green, renewable, or low-carbon? A framework for informed solvent selection in pharmaceutical sciences.

Journal of pharmaceutical sciences·2026
Same journal

Theranostic potential of ramucirumab functionalized magnetoliposomes for targeted delivery of sorafenib and MRI.

Journal of pharmaceutical sciences·2026
Same journal

Intranasal mucoadhesive chitosan microspheres of ranolazine: Formulation, design, and pharmacokinetic evaluation.

Journal of pharmaceutical sciences·2026
Same journal

Evolving landscape of drug development for pediatric rare diseases-from successes to strategies for addressing unmet needs.

Journal of pharmaceutical sciences·2026
Same journal

A mathematical framework for predicting tablet weight variability from blend particle size distribution and tooling geometry.

Journal of pharmaceutical sciences·2026
See all related articles

This study analyzes thermodynamic data for cyclodextrin complex formation. Beta- and gamma-cyclodextrins show stronger binding affinities than alpha-cyclodextrins, indicating their greater potential in molecular encapsulation applications.

Area of Science:

  • Supramolecular Chemistry
  • Physical Chemistry
  • Analytical Chemistry

Background:

  • Cyclodextrins are cyclic oligosaccharides widely used for molecular encapsulation.
  • Understanding the thermodynamics of cyclodextrin complexation is crucial for optimizing their applications.
  • Previous studies have reported diverse thermodynamic data for cyclodextrin-guest interactions.

Purpose of the Study:

  • To compile and statistically analyze literature data on the thermodynamics of 1:1 complex formation for alpha-, beta-, and gamma-cyclodextrins.
  • To determine the population distribution of Gibbs free energy (ΔG°), enthalpy (ΔH°), and entropy (TΔS°) changes.
  • To correlate thermodynamic parameters with binding constants for different cyclodextrin types.

Main Methods:

  • Systematic literature search for thermodynamic data (ΔG°, ΔH°, TΔS°) of cyclodextrin complexation.

Related Experiment Videos

  • Statistical analysis of collected data to determine population means and standard deviations.
  • Calculation of binding constants from mean ΔG° values at 298.15 K.

    • Main Results:

    • Thermodynamic parameters for alpha-, beta-, and gamma-cyclodextrins form normally distributed populations.
    • Mean binding constants at 298.15 K were calculated: 123 M⁻¹ for α-CD, 490 M⁻¹ for β-CD, and 525 M⁻¹ for γ-CD.
    • Statistical parameters (mean and standard deviation) for ΔG°, ΔH°, and TΔS° were reported for each cyclodextrin type.

    Conclusions:

    • Beta- and gamma-cyclodextrins exhibit significantly higher binding affinities compared to alpha-cyclodextrin.
    • The statistical analysis provides a robust overview of the thermodynamic landscape for cyclodextrin complexation.
    • These findings aid in selecting appropriate cyclodextrins for specific molecular recognition and encapsulation tasks.