Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Brazilian hydroxyapatite implant.

D R Jordan¹, I Hwang, T McEachren

¹Department of Ophthalmology, University of Ottawa Eye Institute, Ontario, Canada.

Ophthalmic Plastic and Reconstructive Surgery

|October 6, 2000

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A structured approach to promote equity in spatial accessibility to TB services during private sector engagement.

IJTLD open·2026

Same author

Prenatal and postnatal exposure to butylparaben induces neurodevelopmental disorders in mice offspring.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society·2025

Same author

The genetic architecture of temperature-induced partial fertility restoration in A<sub>1</sub> cytoplasm in sorghum (Sorghum bicolor (L.) Moench).

TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·2025

Same author

Novel proteolysis-targeting chimera targeting RAD51 for the treatment of triple-negative breast cancer.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society·2025

Same author

Systematic screening for skin cancers: Is it a good idea?

Annales de dermatologie et de venereologie·2025

Same author

Treatment of dexamethasone and lenalidomide-resistant multiple myeloma via RAD51 degradation using PROTAC and synergistic effects with chemotherapy.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society·2025

Same journal

Porocarcinoma Arising in a Long-Standing Eviscerated Socket.

Ophthalmic plastic and reconstructive surgery·2026

Same journal

Hyper Immunoglobulin E Syndrome With Conjunctival Molluscum Contagiosum.

Ophthalmic plastic and reconstructive surgery·2026

Same journal

Ethmoiditis Mimicking Acute Dacryocystitis-An Underreported Pathology.

Ophthalmic plastic and reconstructive surgery·2026

Same journal

Orbital Inflammatory Syndrome Associated with Bispecific T-Cell Engager Therapy: Case and Literature Review.

Ophthalmic plastic and reconstructive surgery·2026

Same journal

A Rare Pedunculated Lobular Capillary Hemangioma of the Conjunctiva.

Ophthalmic plastic and reconstructive surgery·2026

Same journal

Core Oculoplastic Procedure Skills for the Comprehensive Ophthalmologist: A Consensus by Delphi Methodology.

Ophthalmic plastic and reconstructive surgery·2026

See all related articles

A Brazilian synthetic hydroxyapatite (HA) implant, while pure HA, is heavier and has an unidentified material. Its porous structure allows vascularization but offers no clinical advantages over other HA implants.

Area of Science:

Ophthalmology
Biomaterials Science
Materials Engineering

Background:

Ocular implants are used to replace the volume of the globe after enucleation.
Synthetic hydroxyapatite (HA) implants offer a biocompatible option for orbital reconstruction.
Evaluating novel biomaterials is crucial for improving patient outcomes in ophthalmology.

Purpose of the Study:

To evaluate the characteristics and biocompatibility of a Brazilian-manufactured synthetic hydroxyapatite (HA) implant.
To compare the Brazilian HA implant with a commercially available implant (BioEye) in a rabbit enucleation model.
To assess fibrovascular ingrowth and histopathological features of the synthetic HA implant.

Main Methods:

Enucleation followed by implantation of Brazilian synthetic HA or BioEye in New Zealand white rabbits.

Related Experiment Videos

Magnetic resonance imaging (MRI) to assess fibrovascular ingrowth at 4, 8, and 12 weeks.

Histopathological examination and chemical/scanning electron microscopy analysis of implants.

Main Results:

The Brazilian HA implant was heavier and possessed a non-uniform porous architecture with random channels and cystic areas.
Histopathology confirmed central vascularization by 4 weeks, indicating host tissue integration.
Unidentified nonbirefringent material was observed in some Brazilian implants; chemical analysis confirmed pure HA.

Conclusions:

The Brazilian HA implant, despite being pure HA, has structural characteristics that do not offer theoretical or clinical advantages.
Its heavier weight and presence of unidentified material are potential drawbacks.
While less expensive to produce, its current availability solely in Brazil and structural properties limit its broader clinical utility.